
Dr. Oliver Wolf is an eccentric but incredibly gifted neurologist who suffers from a rare condition that gives him a unique perspective on care, fueling his mission to change the way the world sees his patients. After his unusual methods result in his dismissal, he takes his unconventional approach to a new hospital: Bronx General, where he leads a team of bright young interns in tackling some of the world's most puzzling psychological cases. With their help, he must also challenge his own personal and social limitations by navigating all the expectations, politics and complicated relationships that come with the job.

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Wolf and Josh's relationship is tested when they tackle a case that hits close to home; Carol and Thorne deal with a patient harboring a huge secret; Van returns and helps Ericka and Dana through their own personal crises.
Wolf treats an anxious teen boy who's faced with a terrifying brain surgery procedure while awake; Carol and Dana investigate possible corruption at Hudson Oaks.
On his first day back at Bronx General, Wolf treats an ex-con who has a medical emergency during a hostage situation; Ericka and Charlie care for a newborn baby in the midst of a life-threatening illness.
Wolf becomes fascinated with an unusual patient at Hudson Oaks who displays signs of being possessed; Carol and Thorne help newlyweds who are struggling with their sex life.