
Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.

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Danny and Gormley race to find Gus Vanderlip, a committed detective who is dangerously determined to uncover how a rapist he arrested is back on the streets; on the eve of their anniversary, Jamie and Eddie are sent on an undercover assignment.
The Reagans' professional lives converge when an allegation of jury tampering against Erin intertwines with Danny and Baez's homicide case; Frank clashes with his friend and confidant, Archbishop Kearns over the death penalty.
Danny works with British investigator Christopher Granger to pursue an international fugitive; Erin faces pressure from her boss to secure an indictment against an officer; Jamie investigates a sports gambling website accused of scamming.
Frank intervenes when tensions rise between Mayor Chase and the fire commissioner of New York City; Erin is blindsided when Henry agrees to testify for the defense in a case she is prosecuting; human remains are discovered in a storage unit.