
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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A priest is admitted to the ER after he sees a bleeding Jesus hovering at his doorstep; House confronts Thirteen and Foreman about their relationship.
The team treats a teenager who doesn't know that he has genetic mosaicism; Wilson and Cuddy think something is wrong with House when he starts acting nice.
House and the team treat a patient who speaks his mind uncontrollably; House thinks Taub and Wilson are keeping something from him.
House sets out to disprove the allegations of a nursing home worker who feigns illness after being visited by the facility's pet cat, which has a reputation for visiting people who are about to die.