
Rebooting the hit movie franchise of the same name, "Lethal Weapon" is set in modern-day Los Angeles, where Detective Roger Murtaugh works a crime-ridden beat. Some of Murtaugh's colleagues at the LAPD include Detective Bailey, Capt. Brooks Avery, and a pathologist named Scorsese. Murtaugh, married to Trish, and a father of three, finds himself working with Detective Wesley Cole, a former international CIA operative who has been everywhere and seen everything. Cole must adjust to life on the West Coast while navigating his partnership with Murtaugh.

On Murtaugh's first day as interim captain, the wife of a popular businessman is abducted; the squad finds a connection in the case to Riggs' father; Riggs is left to grapple with his family and work.

The squad is on high alert after an apparent threat is made on Riggs' life; with Murtaugh taking on more responsibility at work, he and Riggs have to deal with their changing relationship; Trish gets caught up in some trouble.